KAYUMBA PIERRE CLAVER TASTE - MASKED QUININE PELLETS FOR FLEXIBLE PEDIATRIC DRUG DOSING

KAYUMBA PIERRE CLAVER TASTE - MASKED QUININE PELLETS FOR FLEXIBLE PEDIATRIC DRUG DOSING

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The mean Parasitaemia Clearance Time (PCT) was 72.8 ± 16.5 h. Quinine efficacy was assessed in 56 children under five years age. No treatment failure was observed, making thereby taste-masked quinine sulphate pellets a means for... Pediatricians are forced to fragment adults dosage forms. The author observed weight variations when quinine tablets were broken into halves and quarters and proposed pellets as alternative to tablet breaking since they offer more flexibility for the dose adaptation to the child body weight. The bioavailability of quinine formulated as taste-masked pellets was good compared to the tablets on the market. For quinine, tablets (200 or 300 mg quinine sulphate)are broken to get pediatric doses. The lack of pediatric drug formulation for the existing as well as new molecules is a worldwide concern. Taste-masked pellets of 300–700 µm of diameter have been produced. Concentrations during steady state (10.4 ± 2.1-14.9 ± 1.0 µg/ml)were in the therapeutic range.

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KAUFMAN, AMIE ILLUMINAE (UAB)(CD)

Honda. Скутеры Tact & Dio. Устройство, техническое обслуживание и ремонт

Чуковский К.И. Барабек

Отсутствует Евангелие Господа и Бога и Спаса нашего Иисуса Христа

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